该文章基于统计模型建立了一种靶区CTV到PTV的非均匀外扩方法。在保证相同置信度的情况下，考虑到旋转和平移的不确定性对CTV和PTV边界的影响，对非均匀CTV－PTV进行扩展，非均匀外扩后的PTV体积更小，有利于附近危及器官的保护。
", "ds_source": "本文实现了一种由旋转和平移不确定性引起的非均匀临床靶体积(CTV)到计划靶体积(PTV)边缘的方法，并在治疗规划系统(TPS)中进行了评估。材料与方法：基于先前发表的统计模型，建立了目标边缘与距离d (从等心到靶点)、设置不确定性和显著性水平的关系。对于单个CTV，可以认为是多个小体积元素或目标点的组合。利用所提出的统计模型可以得到各点的边际。整个非均匀CTV-PTV边缘是由CTV边界点所有可能边缘的联合决定的。该方法在Pinnacle3治疗计划系统中实现，并与均匀边缘算法进行比较。选取10个椎体转移靶点和多个脑转移靶点进行评价。计算了各种初始平动裕度和转动不确定度下组合CTV-PTV裕度随d的函数。组合裕度随d增大，转动不确定度和平移裕度增大。对于相同的转动不确定度，较小的初始平移裕度需要较大的转动裕度来补偿转动误差。与均匀裕度算法相比，该方法的优点在于，对于给定的CTV，可以使PTVs体积最小化，从而获得相同的显著性水平。利用椎体转移靶点和多个脑转移靶点，针对各种平移边缘和旋转不确定度，得到一系列体积差异。当平移裕度为2mm，旋转不确定度为1.4 °时，PTV的体积差可达到17 %以上
", "ds_process_way": "选取10个椎体转移靶点和多个脑转移靶点进行评价。计算了各种初始平动裕度和转动不确定度下组合CTV-PTV裕度随d的函数。
", "ds_quality": "数据质量良好
", "ds_acq_start_time": "2017-07-01 00:00:00", "ds_acq_end_time": "2019-12-31 00:00:00", "ds_acq_place": "甘肃兰州", "ds_acq_lon_east": null, "ds_acq_lat_south": null, "ds_acq_lon_west": null, "ds_acq_lat_north": null, "ds_acq_alt_low": null, "ds_acq_alt_high": null, "ds_share_type": "apply-access", "ds_total_size": 2350167, "ds_files_count": 2, "ds_format": "pdf", "ds_space_res": null, "ds_time_res": "", "ds_coordinate": "无", "ds_projection": "", "ds_thumbnail": "0cd6b394-0d19-4b9c-a8a2-c75ec4440874.png", "ds_thumb_from": 0, "ds_ref_way": "", "paper_ref_way": "", "ds_ref_instruction": "", "ds_from_station": null, "organization_id": "9971252d-7beb-4464-bc08-bdcc5a1d7dd1", "ds_serv_man": "敏玉芳", "ds_serv_phone": "0931-4967596", "ds_serv_mail": "ncdc@lzb.ac.cn", "doi_value": "", "subject_codes": [], "quality_level": 3, "publish_time": "2023-07-19 11:00:19", "last_updated": "2023-07-21 02:10:05", "protected": false, "protected_to": null, "lang": "zh", "cstr": "11738.11.NCDC.IMP.DB2903.2023", "i18n": { "en": { "title": "A study of nonuniform CTV to PTV margin expansion incorporating both rotational and translational uncertainties", "ds_format": "", "ds_source": "In this paper, a method of non-uniform clinical target volume (CTV) to the edge of planned target volume (PTV) caused by rotation and translation uncertainty is implemented and evaluated in the treatment planning system (TPS). Materials and methods: Based on the previously published statistical model, the relationship between target edge and distance D (from isocenter to target), setting uncertainty and significance level was established. For a single CTV, it can be considered as a combination of multiple small volume elements or target points. Using the proposed statistical model, the marginal values of each point can be obtained. The whole edge of non-uniform CTV-PTV is determined by the combination of all possible edges of CTV boundary points. This method is implemented in pinnacle3 treatment planning system and compared with uniform edge algorithm. Ten vertebral metastasis targets and multiple brain metastasis targets were selected for evaluation. The function of combined CTV-PTV margin with D is calculated under various initial translational margin and rotational uncertainty. With the increase of combination margin, the rotation uncertainty and translation margin increase. For the same rotational uncertainty, a smaller initial translation margin needs a larger rotational margin to compensate for the rotational error. Compared with the uniform margin algorithm, the advantage of this method is that for a given CTV, the volume of PTVs can be minimized and the same significance level can be obtained. Using vertebral metastasis targets and multiple brain metastasis targets, a series of volume differences were obtained for various translation edge and rotation uncertainties. When the translation margin is 2 mm, the rotation uncertainty is 1.4 ° The volume difference of PTV is more than 17%
", "ds_quality": "Good data quality
", "ds_ref_way": "", "ds_abstract": "Based on the statistical model, a non-uniform spreading method from CTV to PTV is proposed. Under the condition of the same confidence, considering the influence of the uncertainty of rotation and translation on the boundary of CTV and PTV, the non-uniform CTV-PTV is expanded. The volume of PTV after non-uniform expansion is smaller, which is conducive to the protection of nearby organs
", "ds_time_res": "", "ds_acq_place": "", "ds_space_res": "", "ds_projection": "", "ds_process_way": "Ten vertebral metastasis targets and multiple brain metastasis targets were selected for evaluation. The function of combined CTV-PTV margin with D is calculated under various initial translational margin and rotational uncertainty.
", "ds_ref_instruction": "" } }, "submit_center_id": "ncdc", "data_level": 0, "license_type": "CC BY 4.0", "doi_reg_from": "reg_local", "cstr_reg_from": "reg_local", "doi_not_reg_reason": null, "cstr_not_reg_reason": null, "is_paper_in_submitting": false, "ds_topic_tags": [ "非均匀、CTV-PRTV边缘扩展", "椎体转移靶点", "多个脑部转移靶点" ], "ds_subject_tags": [], "ds_class_tags": [], "ds_locus_tags": [ "兰州", "甘肃省" ], "ds_time_tags": [ 2017, 2018, 2019 ], "ds_contributors": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "ds_meta_authors": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "ds_managers": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "category": "其他" }