本课题以已有的粒子束治疗为基础，结合现有光子放疗中的先进技术和粒子束治疗系统研发平台，优化现有放疗方案，形成了多模式引导的多粒子联合生物适形调强治疗技术。本课题基于理论分析和计算机模拟等手段，通过用于磁共振图像引导粒子适形调强放疗的快速蒙特卡洛与验证方法研究，建立了复杂磁场、适形调强放疗多粒子束和患者的蒙特卡洛模拟高精度三维模型。根据放疗计划系统提供的适形调强多粒子放疗计划，进行了照射源的建模。构建了基于GPU加速的粒子放疗蒙特卡洛验证软件和基于CPU/GPU异构并行计算硬件，通过对软件整体进行容错处理和性能优化，提高了计算稳定性和速度，实现了快速的蒙特卡洛计算。进一步采用成熟的商用蒙特卡洛软件和基于GPU加速器的粒子放疗蒙特卡洛验证计算结果。开展了磁共振引导的多粒子联合适形调强的蒙特卡洛模拟与验证，研究了复杂磁场环境下光子、电子、质子以及碳离子等多粒子在人体内相互作用，精确模拟了多粒子处于复杂磁场环境下在患者体内非均匀介质下的相互作用。
", "ds_source": "以已有的粒子束治疗为基础，结合现有光子放疗中的先进技术和粒子束治疗系统研发平台，优化现有放疗方案，形成了多模式引导的多粒子联合生物适形调强治疗技术。
", "ds_process_way": "用搭建的CPU与GPU加速的蒙卡平台，采用topas软件进行模拟，获得粒子输运结果图，进而用origin等作图软件对进行数据处理。
", "ds_quality": "数据质量良好
", "ds_acq_start_time": "2017-07-01 00:00:00", "ds_acq_end_time": "2019-12-31 00:00:00", "ds_acq_place": "甘肃兰州", "ds_acq_lon_east": null, "ds_acq_lat_south": null, "ds_acq_lon_west": null, "ds_acq_lat_north": null, "ds_acq_alt_low": null, "ds_acq_alt_high": null, "ds_share_type": "apply-access", "ds_total_size": 126225709, "ds_files_count": 2, "ds_format": "pdf", "ds_space_res": null, "ds_time_res": "", "ds_coordinate": "无", "ds_projection": "", "ds_thumbnail": "1cf54022-a173-4f52-91b3-6935b267f6ca.png", "ds_thumb_from": 0, "ds_ref_way": "", "paper_ref_way": "", "ds_ref_instruction": "", "ds_from_station": null, "organization_id": "9971252d-7beb-4464-bc08-bdcc5a1d7dd1", "ds_serv_man": "敏玉芳", "ds_serv_phone": "0931-4967596", "ds_serv_mail": "ncdc@lzb.ac.cn", "doi_value": "", "subject_codes": [], "quality_level": 3, "publish_time": "2023-08-25 09:38:54", "last_updated": "2023-08-28 15:45:04", "protected": false, "protected_to": null, "lang": "zh", "cstr": "11738.11.NCDC.IMP.DB3934.2023", "i18n": { "en": { "title": "Monte-Carlo simulation and verification of magnetic resonance image-guided multi-particle conformal intensity modulation", "ds_format": "", "ds_source": "Based on the existing particle beam therapy, combined with the existing advanced technology in photon radiotherapy and the research and development platform of particle beam therapy system, the existing radiotherapy scheme is optimized, and the multi-mode guided multi particle combined with biological intensity-modulated therapy technology is formed.
", "ds_quality": "Good data quality
", "ds_ref_way": "", "ds_abstract": "Based on the existing particle beam therapy, combined with the existing advanced technology in photon radiotherapy and the particle beam therapy system development platform, this project optimizes the existing radiotherapy scheme, and forms a multi-mode guided multi particle combined with biological intensity-modulated therapy technology. Based on the theoretical analysis and computer simulation, a high-precision three-dimensional Monte Carlo simulation model of complex magnetic field, multi particle beam and patient was established through the research of fast Monte Carlo simulation and validation method for MRI guided particle intensity modulated radiation therapy (IMRT). According to the IMRT plan provided by the radiotherapy planning system, the radiation source is modeled. The GPU accelerated Monte Carlo verification software and CPU / GPU heterogeneous parallel computing hardware are constructed. Through fault-tolerant processing and performance optimization of the software, the stability and speed of calculation are improved, and the fast Monte Carlo calculation is realized. The results were further verified by using mature commercial Monte Carlo software and particle radiotherapy Monte Carlo based on GPU accelerator. The Monte Carlo simulation and verification of magnetic resonance guided multi particle joint intensity modulation were carried out. The interaction of photons, electrons, protons, carbon ions and other multi particles in the human body under complex magnetic field environment was studied, and the interaction of multi particles in the heterogeneous medium in the patient's body under complex magnetic field environment was accurately simulated.
", "ds_time_res": "", "ds_acq_place": "Lanzhou, Gansu", "ds_space_res": "", "ds_projection": "", "ds_process_way": "Using the built CPU and GPU accelerated Monka platform, the Topas software is used to simulate the particle transport results, and then the Origin software is used to process the data.
", "ds_ref_instruction": "" } }, "submit_center_id": "ncdc", "data_level": 0, "recommendation_value": 0, "license_type": "https://creativecommons.org/licenses/by/4.0/", "doi_reg_from": "reg_local", "cstr_reg_from": "reg_local", "doi_not_reg_reason": null, "cstr_not_reg_reason": null, "is_paper_in_submitting": false, "belong_to_nieer": false, "ds_topic_tags": [ "磁共振图像", "图像引导", "蒙特卡洛模拟" ], "ds_subject_tags": [], "ds_class_tags": [], "ds_locus_tags": [ "兰州", "甘肃省" ], "ds_time_tags": [ 2017, 2018, 2019 ], "ds_contributors": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "ds_meta_authors": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "ds_managers": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "category": "其他" }