该文档是一份联合粒子的治疗计划设计方案，用于描述光子、碳离子及其他粒子的多粒子联合条件下，对患者实施治疗的最佳治疗计划的设计，包括射野数量及方向、照射时间、治疗剂量大小等信息，对于发挥多粒子联合治疗的优势、提高治疗增益、减少正常组织的损伤具有重要意义。
", "ds_source": "使用自主知识产权的国产医用重离子加速器，结合目前临床先进光子调强放疗技术等，发展多模式引导的多种粒子束联合放疗技术，建立基于光子、碳离子和其他粒子联合的治疗计划设计方案。通过联合治疗方案的依据，靶区定义和设计、处方剂量、正常组织保护集剂量限值和方案评估等方面对方案进行了全面阐述。建立并评估多粒子联合治疗方案2套，剂量学研究表明联合治疗其较单独X线计划在正常组织保护方面有明显优势，同时重离子对于肿瘤具有更高的生物等效剂量，以提高肿瘤的控制概率。并且完成《多粒子单独或联合放疗计划的设计、检测和验证报告》。利用重离子强大的生物杀伤效应及剂量分布特点，对肿瘤靶区进行局部推量。不仅能改善剂量分布的适形度也保证了肿瘤达到治疗剂量，提高疗效，同时更好的保护了周围正常组织，减少放疗的毒副作用。
", "ds_process_way": "自主知识产权的国产医用重离子加速器，结合目前临床先进光子调强放疗技术等，发展多模式引导的多种粒子束联合放疗技术，建立基于光子、碳离子和其他粒子联合的治疗计划设计方案。
", "ds_quality": "数据质量良好
", "ds_acq_start_time": "2017-07-01 00:00:00", "ds_acq_end_time": "2019-12-31 00:00:00", "ds_acq_place": "甘肃兰州", "ds_acq_lon_east": null, "ds_acq_lat_south": null, "ds_acq_lon_west": null, "ds_acq_lat_north": null, "ds_acq_alt_low": null, "ds_acq_alt_high": null, "ds_share_type": "apply-access", "ds_total_size": 26177527, "ds_files_count": 2, "ds_format": "pdf", "ds_space_res": null, "ds_time_res": "", "ds_coordinate": "无", "ds_projection": "", "ds_thumbnail": "1d1b652e-fdff-4d53-9b2e-1f36be11cf13.png", "ds_thumb_from": 0, "ds_ref_way": "肖国青，基于光子、碳离子和其他粒子联合的治疗计划设计方案，国家冰川冻土沙漠科学数据中心(http://www.ncdc.ac.cn/)，2021，doi：10.12072/ncdc.IMP.db2514.2022", "paper_ref_way": "", "ds_ref_instruction": "", "ds_from_station": null, "organization_id": "9971252d-7beb-4464-bc08-bdcc5a1d7dd1", "ds_serv_man": "敏玉芳", "ds_serv_phone": "0931-4967596", "ds_serv_mail": "ncdc@lzb.ac.cn", "doi_value": "", "subject_codes": [], "quality_level": 3, "publish_time": "2022-08-26 17:35:03", "last_updated": "2022-12-04 02:10:14", "protected": false, "protected_to": null, "lang": "zh", "cstr": "11738.11.ncdc.IMP.db2514.2022", "i18n": { "en": { "title": "Design scheme based on a combination of photons, carbon ions and other particles", "ds_format": "", "ds_source": "\nUsing the domestic medical heavy ion accelerator with independent intellectual property rights, combined with the current clinical advanced photon intensity-modulated radiotherapy technology, we will develop multi-mode guided multiple particle beam combined radiotherapy technology, and establish a treatment plan design scheme based on the combination of photons, carbon ions and other particles. Based on the basis of the combined treatment scheme, the definition and design of the target area, the prescription dose, the dose limit of the normal tissue protection set and the evaluation of the scheme were comprehensively described. Two sets of multi particle combined therapy schemes were established and evaluated. The dosimetry study showed that the combined therapy has obvious advantages in normal tissue protection compared with the single X-ray plan. Meanwhile, the heavy ion has a higher bioequivalent dose for the tumor, so as to improve the control probability of the tumor. And complete the design, testing and verification report of multi particle single or combined radiotherapy plan. The strong biological killing effect and dose distribution characteristics of heavy ions are used to locally push the tumor target area. It can not only improve the conformal degree of dose distribution, but also ensure that the tumor reaches the therapeutic dose and improves the curative effect, but also better protect the surrounding normal tissues and reduce the toxic and side effects of radiotherapy", "ds_quality": "
\nGood data quality
", "ds_ref_way": "", "ds_abstract": " This document is a treatment plan design scheme of combined particles, which is used to describe the design of the best treatment plan for patients under the condition of multi particle combination of photons, carbon ions and other particles, including the number and direction of the radiation field, irradiation time, treatment dose size and other information, which is helpful for giving full play to the advantages of multi particle combined treatment, improving treatment gain, improving the quality of life It is important to reduce the damage of normal tissue.\n Domestic medical heavy ion accelerator with independent intellectual property rights, combined with the current clinical advanced photon intensity-modulated radiotherapy technology, develops multi-mode guided multi particle beam combined radiotherapy technology, and establishes the treatment plan design scheme based on the combination of photon, carbon ion and other particles.\n