该文章通过回顾性分析194例无远处转移的头颈部黏膜恶性黑色素瘤患者的病例资料，探讨该疾病手术联合放疗的综合治疗模式的效果和失败模式，并分析影响预后的因素，为该疾病的治疗提供参考建议，以进一步提升该疾病的治疗效果，找到更好的治疗方案。
", "ds_source": "83例患者接受单纯手术治疗，15例患者接受单纯放疗，96例患者接受手术联合放疗（术前放疗+手术治疗50例，手术治疗+术后放疗46例）。179例接受手术治疗的患者中，157例患者术后切缘信息完整，切缘阴性 106例， 切缘阳性51例；其中56例行颈部淋巴结清扫术。111例接受放疗的患者中，常规放疗67例，调强放疗44例。 根治性放疗的中位总剂量为49Gy(28~80Gy)，仅有1例达到80Gy，术前放疗中位总剂量为40Gy（20~70Gy），术后放疗中位总剂量为67Gy（36~76Gy），颈部预防性放疗的总剂量为24~60Gy，单次分割剂量为2-8Gy。87例接受化疗的患者均为辅助化疗，治疗方案为达卡巴嗪+长春新碱+顺铂。
", "ds_process_way": "采用SPSS20.0软件行KaplanMeier法计算生存率并Logrank法检验，Cok模型多因素分析，余用χ2检验。P＜0.05为差异有统计学意义。
", "ds_quality": "数据质量良好
", "ds_acq_start_time": "2017-07-01 00:00:00", "ds_acq_end_time": "2019-12-31 00:00:00", "ds_acq_place": "甘肃兰州", "ds_acq_lon_east": null, "ds_acq_lat_south": null, "ds_acq_lon_west": null, "ds_acq_lat_north": null, "ds_acq_alt_low": null, "ds_acq_alt_high": null, "ds_share_type": "apply-access", "ds_total_size": 809160, "ds_files_count": 2, "ds_format": "pdf", "ds_space_res": null, "ds_time_res": "", "ds_coordinate": "无", "ds_projection": "", "ds_thumbnail": "32147d55-4b6e-49ae-8140-f638225f28e6.png", "ds_thumb_from": 0, "ds_ref_way": "", "paper_ref_way": "", "ds_ref_instruction": "", "ds_from_station": null, "organization_id": "9971252d-7beb-4464-bc08-bdcc5a1d7dd1", "ds_serv_man": "敏玉芳", "ds_serv_phone": "0931-4967596", "ds_serv_mail": "ncdc@lzb.ac.cn", "doi_value": "", "subject_codes": [], "quality_level": 3, "publish_time": "2023-08-25 09:38:55", "last_updated": "2023-08-28 15:45:04", "protected": false, "protected_to": null, "lang": "zh", "cstr": "11738.11.NCDC.IMP.DB3935.2023", "i18n": { "en": { "title": "Prognostic analysis of surgery combined with radiotherapy for head and neck mucosal malignant melanoma", "ds_format": "", "ds_source": "83 patients received surgery alone, 15 patients received radiotherapy alone, 96 patients received surgery combined with radiotherapy (preoperative radiotherapy + surgery in 50 cases, surgery + postoperative radiotherapy in 46 cases). Among the 179 patients who received surgical treatment, 157 patients had complete resection margin information, 106 patients had negative resection margin and 51 patients had positive resection margin; Among them, 56 cases underwent neck lymph node dissection. Among 111 patients receiving radiotherapy, 67 received conventional radiotherapy and 44 received intensity modulated radiotherapy. The median total dose of radical radiotherapy was 49gy (28-80gy), and only one case reached 80gy. The median total dose of preoperative radiotherapy was 40gy (20-70gy), the median total dose of postoperative radiotherapy was 67gy (36-76gy), the total dose of cervical preventive radiotherapy was 24-60gy, and the single split dose was 2-8gy. 87 cases of patients receiving chemotherapy were adjuvant chemotherapy, the treatment regimen was dacarbazine + vincristine + cisplatin.
", "ds_quality": "Good data quality
", "ds_ref_way": "", "ds_abstract": "In this paper, 194 cases of malignant melanoma of head and neck mucosa without distant metastasis were retrospectively analyzed to explore the effect and failure mode of the comprehensive treatment mode of surgery combined with radiotherapy, and analyze the factors affecting the prognosis, so as to provide reference suggestions for the treatment of the disease, so as to further improve the treatment effect of the disease and find a better treatment scheme.
", "ds_time_res": "", "ds_acq_place": "Lanzhou, Gansu", "ds_space_res": "", "ds_projection": "", "ds_process_way": "Spss20.0 software was used for Kaplan analysis Meier method was used to calculate the survival rate, and logrank method was used to test the survival rate χ 2 inspection. P < 0.05 for the difference was statistically significant.
", "ds_ref_instruction": "" } }, "submit_center_id": "ncdc", "data_level": 0, "recommendation_value": 0, "license_type": "https://creativecommons.org/licenses/by/4.0/", "doi_reg_from": "reg_local", "cstr_reg_from": "reg_local", "doi_not_reg_reason": null, "cstr_not_reg_reason": null, "is_paper_in_submitting": false, "belong_to_nieer": false, "ds_topic_tags": [ "头颈部", "黑色素瘤", "雨后分析" ], "ds_subject_tags": [], "ds_class_tags": [], "ds_locus_tags": [ "兰州", "甘肃省" ], "ds_time_tags": [ 2017, 2018, 2019 ], "ds_contributors": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "ds_meta_authors": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "ds_managers": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "category": "其他" }