该文章是在一项头颈鳞癌的术前放疗的3期临床研究中，确定术前接受放疗或放化疗的局部晚期头颈部鳞状细胞癌(HNSCC)患者的病理完全缓解(pCR)与临床结局之间的关系，结果显示术前放疗或同步放化疗后的pCR是局部晚期头颈部鳞状细胞癌良好的预后因素。
", "ds_source": "本研究旨在通过一项3期临床研究，确定局部晚期头颈部鳞癌(HNSCC)患者术前放疗或放化疗后病理完全缓解(pCR)与临床结局的关系。方法\n将222例新诊断Ⅲ/ⅣM0期HNSCC患者随机分为术前同步放化疗组(n=104 )或术前单纯放疗组(n=118)。在平均59个月的随访中，72例患者被定义为术前治疗无效者，随后接受有或无颈清扫的原发病灶切除术。分析原发病灶的病理肿瘤反应与治疗预后的关系。采用Kaplan-Meier和Cox回归多因素分析评价pCR对局部控制率(LC)、总生存期(OS)、无进展生存期(PFS)及总生存期(OS)的影响。
", "ds_process_way": "将222例新诊断Ⅲ/ⅣM0期HNSCC患者随机分为术前同步放化疗组(n=104 )或术前单纯放疗组(n=118)。在平均59个月的随访中，72例患者被定义为术前治疗无效者，随后接受有或无颈清扫的原发病灶切除术。分析原发病灶的病理肿瘤反应与治疗预后的关系。
", "ds_quality": "数据质量良好
", "ds_acq_start_time": "2017-07-01 00:00:00", "ds_acq_end_time": "2019-12-31 00:00:00", "ds_acq_place": "甘肃兰州", "ds_acq_lon_east": null, "ds_acq_lat_south": null, "ds_acq_lon_west": null, "ds_acq_lat_north": null, "ds_acq_alt_low": null, "ds_acq_alt_high": null, "ds_share_type": "apply-access", "ds_total_size": 1394921, "ds_files_count": 2, "ds_format": "pdf", "ds_space_res": null, "ds_time_res": "", "ds_coordinate": "无", "ds_projection": "", "ds_thumbnail": "411832d2-b363-4e8d-a53d-20fef2eaf831.png", "ds_thumb_from": 0, "ds_ref_way": "", "paper_ref_way": "", "ds_ref_instruction": "", "ds_from_station": null, "organization_id": "9971252d-7beb-4464-bc08-bdcc5a1d7dd1", "ds_serv_man": "敏玉芳", "ds_serv_phone": "0931-4967596", "ds_serv_mail": "ncdc@lzb.ac.cn", "doi_value": "", "subject_codes": [], "quality_level": 3, "publish_time": "2023-08-25 09:38:55", "last_updated": "2023-08-27 15:45:04", "protected": false, "protected_to": null, "lang": "zh", "cstr": "11738.11.NCDC.IMP.DB3937.2023", "i18n": { "en": { "title": "Prognostic impact of pathological complete remission after preoperative irradiation in patients with locally advanced head and neck squamous cell carcinoma: re-analysis of a phase 3 clinical stud", "ds_format": "", "ds_source": "The purpose of this study was to determine the relationship between pathological complete response (PCR) and clinical outcomes in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) after preoperative radiotherapy or chemoradiotherapy. method\nMethods: 222 patients with newly diagnosed stage Ⅲ / Ⅳ M0 HNSCC were randomly divided into preoperative concurrent chemoradiotherapy group (n = 104) and preoperative radiotherapy group (n = 118). During a mean follow-up of 59 months, 72 patients were defined as having failed preoperative treatment and subsequently underwent primary lesion resection with or without neck dissection. Objective to analyze the relationship between the pathological reaction of primary lesions and the prognosis. Kaplan Meier and Cox regression analysis were used to evaluate the effect of PCR on local control rate (LC), overall survival (OS), progression free survival (PFS) and overall survival (OS).
", "ds_quality": "Good data quality
", "ds_ref_way": "", "ds_abstract": "In a phase 3 clinical study of preoperative radiotherapy for head and neck squamous cell carcinoma (HNSCC), the relationship between pathological complete response (PCR) and clinical outcome in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) who received preoperative radiotherapy or chemoradiotherapy was determined. The results showed that PCR after preoperative radiotherapy or concurrent chemoradiotherapy was a good prognostic factor for locally advanced head and neck squamous cell carcinoma.
", "ds_time_res": "", "ds_acq_place": "", "ds_space_res": "", "ds_projection": "", "ds_process_way": "Methods: 222 patients with newly diagnosed stage Ⅲ / Ⅳ M0 HNSCC were randomly divided into preoperative concurrent chemoradiotherapy group (n = 104) and preoperative radiotherapy group (n = 118). During a mean follow-up of 59 months, 72 patients were defined as having failed preoperative treatment and subsequently underwent primary lesion resection with or without neck dissection. Objective to analyze the relationship between the pathological reaction of primary lesions and the prognosis.
", "ds_ref_instruction": "" } }, "submit_center_id": "ncdc", "data_level": 0, "license_type": "CC BY 4.0", "doi_reg_from": "reg_local", "cstr_reg_from": "reg_local", "doi_not_reg_reason": null, "cstr_not_reg_reason": null, "is_paper_in_submitting": false, "ds_topic_tags": [ "局部晚期", "鳞癌", "预后" ], "ds_subject_tags": [], "ds_class_tags": [], "ds_locus_tags": [ "甘肃省", "兰州" ], "ds_time_tags": [ 2017, 2018, 2019 ], "ds_contributors": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "ds_meta_authors": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "ds_managers": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "category": "其他" }