本文使用MCNP5蒙特卡洛粒子输运软件包建立Nucletron-mHDR-V1192Ir放射源模型，并放入由患者在不同膀胱充盈度时拍摄的CT图像转换得到的三维体素模型，模拟不同膀胱充盈度对宫颈癌近距离放疗的影响。其中处方剂量为60Gy，按ICRU 38号报告推荐方法选取各参考点，采用单管施源器，放射源位置共分为18个步长，每个步长距离为5mm。结果显示，参考点A点吸收剂量为60 Gy，膀胱充盈度为54mL时：膀胱参考点的吸收剂量为30.21 Gy，直肠参考点的吸收剂量为49.05 Gy，股骨头参考点的吸收剂量为6.33 Gy（左）、6.39 Gy（右）；膀胱充盈度为328 mL时：膀胱参考点的吸收剂量为33.59 Gy，直肠参考点的吸收剂量为50.19 Gy，股骨头参考点的吸收剂量为6.15 Gy（左）、6.12 Gy（右）。分析膀胱壁上各体素的吸收剂量，得到膀胱的剂量体积直方图，膀胱充盈度为54 mL时：V10=100%，V20=39.69%，V30=26.20%，V40=17.89%，V50=14.48%，V60=11.69%；膀胱充盈度为328 mL时：V10=86.07%，V20=26.53%，V30=15.58%，V40=9.44%，V50=6.01%，V60=3.72%。得出的结论为膀胱充盈度为328mL相对于膀胱充盈度为54mL时，直肠、股骨头参考点的吸收剂量没有显著变化，虽然膀胱参考点的吸收剂量有所增加（3.38 Gy），但在剂量体积直方图中所有剂量点处，膀胱的受照体积均有比较明显的减少（剂量为20 Gy时受照体积减少13.16%，剂量为40 Gy时受照体积减少8.45%，剂量为60 Gy时受照体积减少7.97%），模拟结果对临床宫颈癌的放射治疗有一定指导意义。
", "ds_source": "本文使用MCNP5蒙特卡洛粒子输运软件包建立Nucletron-mHDR-V1192Ir放射源模型，并放入由患者在不同膀胱充盈度时拍摄的CT图像转换得到的三维体素模型，模拟不同膀胱充盈度对宫颈癌近距离放疗的影响。
", "ds_process_way": "本文使用蒙特卡洛方法和三维体素模型加工
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", "ds_acq_start_time": "2017-07-01 00:00:00", "ds_acq_end_time": "2019-12-31 00:00:00", "ds_acq_place": "甘肃兰州", "ds_acq_lon_east": null, "ds_acq_lat_south": null, "ds_acq_lon_west": null, "ds_acq_lat_north": null, "ds_acq_alt_low": null, "ds_acq_alt_high": null, "ds_share_type": "apply-access", "ds_total_size": 7906332, "ds_files_count": 2, "ds_format": "pdf", "ds_space_res": null, "ds_time_res": "", "ds_coordinate": "无", "ds_projection": "", "ds_thumbnail": "527d8000-7b43-4880-a90c-572b56255b7d.png", "ds_thumb_from": 0, "ds_ref_way": "", "paper_ref_way": "", "ds_ref_instruction": "", "ds_from_station": null, "organization_id": "9971252d-7beb-4464-bc08-bdcc5a1d7dd1", "ds_serv_man": "敏玉芳", "ds_serv_phone": "0931-4967596", "ds_serv_mail": "ncdc@lzb.ac.cn", "doi_value": "", "subject_codes": [], "quality_level": 3, "publish_time": "2023-12-27 11:29:37", "last_updated": "2024-01-03 17:20:56", "protected": false, "protected_to": null, "lang": "zh", "cstr": "11738.11.NCDC.IMP.DB4140.2023", "i18n": { "en": { "title": "Effects of different degrees of bladder filling on brachytherapy for cervical cancer based on Monte Carlo simulation", "ds_format": "", "ds_source": "In this paper, MCNP5 Monte Carlo particle transport software package was used to establish the nuclear-mhdr-v1192ir radiation source model, and put in the three-dimensional voxel model which was converted from CT images taken by patients at different bladder filling degrees to simulate the effect of different bladder filling degrees on the brachytherapy of cervical cancer.
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", "ds_ref_way": "", "ds_abstract": "In this paper, MCNP5 Monte Carlo particle transport software package was used to establish the nuclear-mhdr-v1192ir radiation source model, and put in the three-dimensional voxel model which was converted from CT images taken by patients at different bladder filling degrees to simulate the effect of different bladder filling degrees on the brachytherapy of cervical cancer. The prescription dose was 60Gy. The reference points were selected according to the method recommended by ICRU Report No. 38. The single tube applicator was used. The source position was divided into 18 steps, and the distance of each step was 5mm. The results showed that when the absorbed dose of the reference point a was 60 Gy and the bladder filling degree was 54 ml, the absorbed dose of the bladder reference point was 30.21 Gy, the absorbed dose of the rectal reference point was 49.05 Gy, and the absorbed dose of the femoral head reference point was 6.33 Gy (left) and 6.39 Gy (right); When the bladder filling degree was 328 ml, the absorbed dose was 33.59 Gy at the bladder reference point, 50.19 Gy at the rectum reference point, and 6.15 Gy (left) and 6.12 Gy (right) at the femoral head reference point. The absorbed dose of each voxel on the bladder wall was analyzed, and the dose volume histogram of the bladder was obtained. When the bladder filling degree was 54 ml, V10 = 100%, V20 = 39.69%, V30 = 26.20%, V40 = 17.89%, V50 = 14.48%, V60 = 11.69%; When the bladder filling degree was 328 ml: V10 = 86.07%, V20 = 26.53%, V30 = 15.58%, V40 = 9.44%, V50 = 6.01%, V60 = 3.72%. The conclusion is that when the bladder filling degree is 328ml, compared with 54ml, the absorbed dose at the reference point of rectum and femoral head has no significant change. Although the absorbed dose at the reference point of bladder has increased (3.38gy), the irradiated volume of bladder has decreased significantly at all dose points in the dose volume histogram (the irradiated volume has decreased by 13.16% when the dose is 20GY, the absorbed dose at the reference point of rectum and femoral head has increased (3.38gy), The irradiation volume decreased by 8.45% when the dose was 40 Gy, and 7.97% when the dose was 60 Gy). The simulation results have certain guiding significance for the clinical radiotherapy of cervical cancer.
", "ds_time_res": "", "ds_acq_place": "Lanzhou, Gansu", "ds_space_res": "", "ds_projection": "", "ds_process_way": "In this paper, Monte Carlo method and three-dimensional voxel model are used
", "ds_ref_instruction": "" } }, "submit_center_id": "ncdc", "data_level": 0, "license_type": "CC BY 4.0", "doi_reg_from": "reg_local", "cstr_reg_from": "reg_local", "doi_not_reg_reason": null, "cstr_not_reg_reason": null, "is_paper_in_submitting": false, "ds_topic_tags": [ "宫颈癌", "近距离放疗", "膀胱充盈度", "蒙特卡罗方法", "体素模型" ], "ds_subject_tags": [], "ds_class_tags": [], "ds_locus_tags": [ "兰州", "甘肃省" ], "ds_time_tags": [ 2017 ], "ds_contributors": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "ds_meta_authors": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "ds_managers": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "category": "其他" }