本文使用蒙特卡洛方法模拟了在碳离子放疗过程中产生的次级中子对人体主要器官的吸收剂量和当量剂量。基于中国科学院近代物理研究所（IMP）的重离子深层肿瘤治疗的束流配送系统治疗头，使用MCNPX对该系统的初级准直器、脊型过滤器、射程移位器以及多叶准直器进行建模，模拟计算400 MeV/u碳离子均匀照射野经过IMP被动式束流配送系统，入射到RPI-Adult男性体模后，统计全身主要器官内的次级中子能谱和吸收剂量与当量剂量。结果表明，当脑垂体瘤接受治疗并给予50 Gy处方剂量时，不同器官内的中子能谱显示所产生的次级中子能量范围比较大，最大能量高达几百MeV；而且脑部部分器官的中子当量剂量相对比较高，大脑、头盖骨和眼晶体当量剂量为53.18、32.43、33.20mSv；离脑部较远的器官，如胸部、肺以及前列腺剂量很低，都小于0.4 mSv。结论：利用蒙特卡洛方法和计算机仿真人体模型模拟了碳离子放疗过程，并统计了全身大部分器官内次级中子能谱和受到的剂量。本研究计算的结果和结论，再结合相关资料，可以为临床上研究碳离子放疗的远期效应提供参考。
", "ds_source": "本文使用蒙特卡洛方法模拟了在碳离子放疗过程中产生的次级中子对人体主要器官的吸收剂量和当量剂量
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", "ds_acq_start_time": "2017-01-01 00:00:00", "ds_acq_end_time": "2019-12-31 00:00:00", "ds_acq_place": "甘肃兰州", "ds_acq_lon_east": null, "ds_acq_lat_south": null, "ds_acq_lon_west": null, "ds_acq_lat_north": null, "ds_acq_alt_low": null, "ds_acq_alt_high": null, "ds_share_type": "apply-access", "ds_total_size": 8127881, "ds_files_count": 2, "ds_format": "pdf", "ds_space_res": null, "ds_time_res": "", "ds_coordinate": "无", "ds_projection": "", "ds_thumbnail": "6e5b7fa8-ac32-423c-80ec-f474427dbd0c.png", "ds_thumb_from": 0, "ds_ref_way": "", "paper_ref_way": "", "ds_ref_instruction": "", "ds_from_station": null, "organization_id": "9971252d-7beb-4464-bc08-bdcc5a1d7dd1", "ds_serv_man": "敏玉芳", "ds_serv_phone": "0931-4967596", "ds_serv_mail": "ncdc@lzb.ac.cn", "doi_value": "", "subject_codes": [], "quality_level": 3, "publish_time": "2023-12-27 11:29:21", "last_updated": "2023-12-27 11:29:21", "protected": false, "protected_to": null, "lang": "zh", "cstr": "11738.11.NCDC.IMP.DB4142.2023", "i18n": { "en": { "title": "Monte Carlo simulation of secondary neutron dose in major organs in RPI-Adult male phantom during carbon ion radiotherapy", "ds_format": "", "ds_source": "In this paper, Monte Carlo method is used to simulate the absorbed dose and equivalent dose of secondary neutrons generated in the process of carbon ion radiotherapy to the main organs of human body
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", "ds_ref_way": "", "ds_abstract": "In this paper, Monte Carlo method is used to simulate the absorbed dose and equivalent dose of secondary neutrons generated in the process of carbon ion radiotherapy to the main organs of human body. The primary collimator, ridge filter, range shifter and multileaf collimator of the heavy ion beam delivery system of the Institute of Modern Physics (IMP) of the Chinese Academy of sciences are modeled by MCNPX. The simulation results show that the 400 MeV / u carbon ion uniform irradiation field passes through the imp passive beam delivery system and is incident on the RPI adult male phantom, The secondary neutron energy spectrum, absorbed dose and equivalent dose in the main organs of the whole body were calculated. The results show that when the pituitary tumor is treated and given a prescribed dose of 50 Gy, the neutron energy spectrum in different organs shows that the range of secondary neutron energy is relatively large, and the maximum energy is as high as several hundred MeV; The equivalent doses of brain, skull and lens were 53.18, 32.43 and 33.20 mSv; The dose of organs far away from the brain, such as chest, lung and prostate, was very low, less than 0.4 mSv. Conclusion: Monte Carlo method and computer simulation human body model are used to simulate the process of carbon ion radiotherapy, and the secondary neutron energy spectrum and dose in most organs of the whole body are counted. The results and conclusions of this study, combined with relevant data, can provide reference for clinical study of long-term effects of carbon ion radiotherapy.
", "ds_time_res": "", "ds_acq_place": "Lanzhou, Gansu", "ds_space_res": "", "ds_projection": "", "ds_process_way": "Processing of human body model by computer
", "ds_ref_instruction": "" } }, "submit_center_id": "ncdc", "data_level": 0, "license_type": "CC BY 4.0", "doi_reg_from": "reg_local", "cstr_reg_from": "reg_local", "doi_not_reg_reason": null, "cstr_not_reg_reason": null, "is_paper_in_submitting": false, "ds_topic_tags": [ "蒙特卡洛方法", "体素模型", "碳离子", "当量剂量" ], "ds_subject_tags": [], "ds_class_tags": [], "ds_locus_tags": [ "兰州", "甘肃省" ], "ds_time_tags": [ 2017 ], "ds_contributors": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "ds_meta_authors": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "ds_managers": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "category": "其他" }