该数据属于多种粒子的相对生物学效应（relativebiologicaleffectiveness）的测量实验数据，用于描述不同的粒子辐射对肿瘤细胞的损伤大小的性能指标，通过对达到不同物理辐照剂量肿瘤细胞的存活数统计获得相应的细胞存活率，进而通过拟合曲线获得同一生物学终点所需要的粒子辐射剂量和参考辐射如X射线的辐射剂量，计算出所考察粒子辐射对不同肿瘤细胞的相对生物学效应值。
", "ds_source": "该数据属于粒子治疗基础实验数据，在2017年至2020年期间产生的重离子辐照肿瘤细胞效应评估数据，相对生物学效应数据库用于描述不同粒子，如光子、重离子等，辐照肿瘤细胞达到相同生物学终点时所需要的剂量比值，可以评估不同射线对于肿瘤细胞的杀伤能力。
", "ds_process_way": "细胞存活率的数据是通过肿瘤细胞辐照后进行克隆，统计所得克隆群落数，再除以未辐照的肿瘤细胞进行克隆所得的群落数得的比值。物理辐照剂量值是通剂量剂标定后，由治疗计划系统设置一定的值如0、1、2、3、4、5、6Gy。根据所得细胞存活率与辐照剂量进行作图，获得细胞存活与辐照剂量关系图，见opj图，采用线性平方模型进行拟合获得曲线。通过存活曲线选取不同细胞存活率如10%、30%、50%、70%、90%获得相对的物理剂量值。通过同一生物学终点所需的X射线的剂量除以碳离子的剂量即可获得相对生物学效应数据。汇总数据表格中的LET是根据样品摆位的位置（在碳离子束的坪区还是峰区）来确定的。
", "ds_quality": "细胞存活率通过克隆存活实验产生，物理剂量值通过剂量计测量，通过细胞存活率与物理剂量的关系图的线性平方模型拟合获得相对生物学效应数据。
", "ds_acq_start_time": "2017-06-27 00:00:00", "ds_acq_end_time": "2018-08-25 00:00:00", "ds_acq_place": "甘肃,兰州,武威", "ds_acq_lon_east": null, "ds_acq_lat_south": null, "ds_acq_lon_west": null, "ds_acq_lat_north": null, "ds_acq_alt_low": null, "ds_acq_alt_high": null, "ds_share_type": "apply-access", "ds_total_size": 1345358, "ds_files_count": 3, "ds_format": "dat,opj,excel", "ds_space_res": null, "ds_time_res": "年", "ds_coordinate": "无", "ds_projection": "", "ds_thumbnail": "93f491b3-f3d1-4bcf-bcfa-e3800b3e300b.png", "ds_thumb_from": 0, "ds_ref_way": "肖国青，相对生物效应（RBE）基础数据库，国家冰川冻土沙漠科学数据中心(http://www.ncdc.ac.cn/)，2021，doi：10.12072/ncdc.IMP.db2499.2022", "paper_ref_way": "", "ds_ref_instruction": "", "ds_from_station": null, "organization_id": "9971252d-7beb-4464-bc08-bdcc5a1d7dd1", "ds_serv_man": "敏玉芳", "ds_serv_phone": "0931-4967596", "ds_serv_mail": "ncdc@lzb.ac.cn", "doi_value": "", "subject_codes": [], "quality_level": 3, "publish_time": "2022-08-26 17:35:08", "last_updated": "2022-12-03 02:10:08", "protected": false, "protected_to": null, "lang": "zh", "cstr": "11738.11.ncdc.IMP.db2499.2022", "i18n": { "en": { "title": "Database of relative biological effectiveness", "ds_format": "", "ds_source": " This data belongs to the basic experimental data of particle therapy, which is the evaluation data of tumor cell effect of heavy ion irradiation generated from 2017 to 2020. The relative biological effect database is used to describe the dose ratio of different particles, such as photons and heavy ions, when irradiation tumor cells reach the same biological end point, It can evaluate the killing ability of different radiation to tumor cells.\n The cell survival rate was generated by clone survival experiment, the physical dose was measured by dosimeter, and the relative biological effect data was obtained by fitting the linear square model of the relationship between cell survival rate and physical dose.\n This data belongs to the measurement experimental data of relative biological effect of various particles, which is used to describe the performance index of the damage size of tumor cells caused by different particle radiation. The corresponding cell survival rate is obtained by counting the survival number of tumor cells with different physical radiation doses, Then, the radiation dose of particles and reference radiation such as X-ray for the same biological endpoint were obtained by fitting the curve, and the relative biological effects of particles on different tumor cells were calculated.\nThis data belongs to the basic experimental data of particle therapy, which is the evaluation data of tumor cell effect of heavy ion irradiation generated from 2017 to 2020. The relative biological effect database is used to describe the dose ratio of different particles, such as photons and heavy ions, when irradiation tumor cells reach the same biological end point, It can evaluate the killing ability of different radiation to tumor cells.
", "ds_time_res": "年", "ds_acq_place": "Wuwei, Lanzhou, Gansu", "ds_space_res": "", "ds_projection": "", "ds_process_way": " The data of cell survival rate is the ratio of the number of colonies obtained by cloning tumor cells after irradiation and then dividing by the number of colonies obtained by cloning tumor cells without irradiation. The physical radiation dose value is set by the treatment planning system, such as 0, 1, 2, 3, 4, 5, 6gy after the dose agent calibration. According to the cell survival rate and radiation dose, the relationship between cell survival and radiation dose was obtained. See the opj diagram. The curve was fitted by linear square model. Different cell survival rates such as 10%, 30%, 50%, 70% and 90% were selected by survival curve to obtain relative physical dose values. The relative biological effect data can be obtained by dividing the X-ray dose required by the same biological endpoint by the carbon ion dose. The let in the summary data table is determined according to the position of the sample (in the plateau or peak region of the carbon ion beam).\n