组织等效正比计数器(TEPC)广泛应用于重离子束微剂量学测量,提供用于计算相对生物学效应(RBE)的基础数据.为研究TEPC壁对重离子束微剂量学测量及RBE计算的影响,在蒙特卡罗(MC)模拟中引入理想组织等效正比计数器(Ideal-TEPC),精确计算得到碳离子束不同水等效深度处的微剂量学量及RBE.Ideal-TEPC和常规TEPC的计算结果表明:TEPC壁会使碳离子束产生较大的辐射场畸变,且会使TEPC测量结果及RBE计算结果产生较大偏差,该偏差随贯穿深度的增加而增大.将TEPC壁视为具有固定水等效厚度的水层可在数值上抵消TEPC壁对RBE计算的影响,但在展宽Bragg峰(SOBP)后端会产生过修正现象.Ideal-TEPC结合MC模拟能有效避免TEPC壁效应及TEPC壁引起的辐射场畸变对重离子束微剂量学量和RBE计算的影响.
", "ds_source": "采用基于Geant4(10.03)内核的Gate(8.0)MC模拟软件。MC模拟中的物理过程选择QGSP_BIC_HP，该物理过程被广泛应用于辐射防护及生物医学的MC模拟计算。MC模拟中的能量阈值设置为250eV，低于该能量阈值将不会再有次级粒子产生。初始碳离子数目设置为107个，确保MC模拟计算的精度。Geant4在重离子剂量学和微剂量学模拟计算中的准确性已被前人验证。以能量为330MeV/u的单能和具有6CM展宽Bragg峰(SOBP)的展宽碳离子束为例研究TEPC壁对其辐射场的影响，其中SOBP采用基于Kanai等的碳离子束Bragg峰展宽方法。
", "ds_process_way": "本文拟对TEPC壁引起的辐射场畸变对碳离子束微剂量学测量及RBE计算的影响进行研究，评估在实验测量中以固定水等效厚度的水层抵消TEPC壁方法的适用范围，并提出一种 基于理想组织等效正比计数器(Ideal-TEPC)结合MC模拟准确计算微剂量学线能谱及RBE的方法。
", "ds_quality": "数据采用基于Geant4(10.03)内核的Gate(8.0)MC模拟软件。数据科学、良好
", "ds_acq_start_time": "2018-08-30 00:00:00", "ds_acq_end_time": "2018-10-18 00:00:00", "ds_acq_place": "甘肃兰州", "ds_acq_lon_east": null, "ds_acq_lat_south": null, "ds_acq_lon_west": null, "ds_acq_lat_north": null, "ds_acq_alt_low": null, "ds_acq_alt_high": null, "ds_share_type": "apply-access", "ds_total_size": 1108739, "ds_files_count": 2, "ds_format": "pdf", "ds_space_res": null, "ds_time_res": "", "ds_coordinate": "无", "ds_projection": "", "ds_thumbnail": "9f88fd75-8aa0-4ff0-bd9b-2442fa2dd90d.png", "ds_thumb_from": 0, "ds_ref_way": "", "paper_ref_way": "", "ds_ref_instruction": "", "ds_from_station": null, "organization_id": "9971252d-7beb-4464-bc08-bdcc5a1d7dd1", "ds_serv_man": "敏玉芳", "ds_serv_phone": "0931-4967596", "ds_serv_mail": "ncdc@lzb.ac.cn", "doi_value": "", "subject_codes": [], "quality_level": 3, "publish_time": "2023-10-17 18:58:29", "last_updated": "2025-12-26 16:40:11", "protected": false, "protected_to": null, "lang": "zh", "cstr": "11738.11.NCDC.IMP.DB4030.2023", "i18n": { "en": { "title": "Influence of TEPC Wall on Microdosimetric Measurement and Relative Biological Effectiveness Calculation of Heavy Ion Beam", "ds_format": "", "ds_source": "Gate (8.0) MC simulation software based on GEANT4 (10.03) kernel is used. Physical process selection qgsp in MC simulation_ BIC_ HP, which is widely used in radiation protection and biomedical MC simulation. The energy threshold of MC simulation is set to 250 EV, below which no secondary particles will be produced. The initial number of carbon ions is set to 107 to ensure the accuracy of MC simulation. The accuracy of GEANT4 in heavy ion dosimetry and microdosimetry simulation has been verified by predecessors. The effects of TEPC wall on the radiation field of 330 MeV / u single energy and 6 cm broadened Bragg peak (SOBP) carbon ion beams are studied. The SOBP is based on the Bragg peak broadening method of Kanai et al.
", "ds_quality": "Gate (8.0) MC simulation software based on GEANT4 (10.03) kernel was used. The data is scientific and good
", "ds_ref_way": "", "ds_abstract": "Tissue equivalent proportional counter (TEPC) is widely used in heavy ion beam microdosimetry measurement, which provides basic data for calculating relative biological effects (RBE). In order to study the influence of TEPC wall on heavy ion beam microdosimetry measurement and RBE calculation, ideal tissue equivalent proportional counter (ideal TEPC) was introduced into Monte Carlo (MC) simulation, The microdosimetry of carbon ion beam at different water equivalent depths and the calculation results of RBE. Ideal TEPC and conventional TEPC show that the TEPC wall will cause large radiation field distortion of carbon ion beam and large deviation between the measurement results of TEPC and the calculation results of RBE, The deviation increases with the increase of penetration depth. Considering TEPC wall as a water layer with fixed water equivalent thickness, the influence of TEPC wall on RBE calculation can be offset numerically, but there will be over correction at the back end of the broadened Bragg peak (SOBP). Ideal TEPC combined with MC simulation can effectively avoid the influence of TEPC wall effect and radiation field distortion caused by TEPC wall on heavy ion beam microdosimetry and RBE calculation
", "ds_time_res": "", "ds_acq_place": "Lanzhou, Gansu", "ds_space_res": "", "ds_projection": "", "ds_process_way": "In this paper, the influence of radiation field distortion caused by TEPC wall on carbon ion beam microdosimetry measurement and RBE calculation is studied, and the applicability of the method of offsetting TEPC wall with water layer with fixed water equivalent thickness in experimental measurement is evaluated. A method based on ideal tissue equivalent proportional counter (ideal TEPC) combined with MC simulation is proposed to accurately calculate the line energy spectrum and RBE of microdosimetry.
", "ds_ref_instruction": "" } }, "submit_center_id": "ncdc", "data_level": 0, "license_type": "CC BY 4.0", "ds_topic_tags": [ "组织等效正比计数器", "微剂量学", "相对生物学效应", "重离子", "蒙特卡罗模拟" ], "ds_subject_tags": [], "ds_class_tags": [], "ds_locus_tags": [ "兰州", "甘肃省" ], "ds_time_tags": [ 2018 ], "ds_contributors": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "ds_meta_authors": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "ds_managers": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "category": "其他" }