该文章分析了局部晚期(T3､T4期)喉癌颈部淋巴结转移(LNM)规律，为喉癌放疗颈部靶区勾画提供参考，结果显示双侧颈部Ⅱ、Ⅲ区是高危LNM区，Ⅳ、Ⅴ区转移较少见；同侧Ⅱ、Ⅲ区转移是同侧Ⅳ区及对侧颈LNM的相关因素，cN0期患者少见对侧颈LNM。
", "ds_source": "分析局部晚期（T3、T4期）喉癌颈部淋巴结转移（LNM）规律，为喉癌放疗颈部靶区勾画提供参考。回顾分析2000-2017年中国医学科学院肿瘤医院初治局部晚期喉癌患者，所有患者至少行双颈Ⅱ－Ⅳ区淋巴结清扫，计算颈部各区LNM率。 采用Logistic回归分析LNM相关因素。 共272例患者纳入研究，全组患者LNM率为57.1％（156/272）。根据原发病变部位分3个组：Ａ组（72例），原发灶局限于一侧；Ｂ组（8例），原发灶主体偏于一侧但侵犯过中线；Ｃ组（114例），原发灶为巨大或中央型病变。各组不同颈部分区LNM率：Ａ组同侧颈部Ⅱ区36.3％、Ⅲ区26.4％、Ⅳ区6.9％，对侧分别为13.9％、8.3％、１.4％；Ｂ组：同侧颈部Ⅱ区41.9％、Ⅲ区29.1％、Ⅳ区11.6％，对侧分别为18.6％、14.0％、1.2％；Ｃ组：左侧Ⅱ区24.6％、Ⅲ区23.7％、Ⅳ区2.6％，右侧分别为21.9％、26.3％、6.1％。 局限单侧（Ａ组）与中线受侵（B、C组）双侧LNM率相近（15.3％、25.0％，Ｐ＝0.093）。 同侧Ⅲ区是否转移和临床淋巴结分期与对侧颈是否LNM相关（ＯＲ＝2.929，95％ＣＩ为1.041～8.245，Ｐ＝0.042）和OR＝0.082，95％ＣＩ为0.018～0.373，Ｐ＝0.001）。同侧Ⅱ区、Ⅲ区转移是同侧Ⅳ区转移的危险因素（Ｐ＝0.043、0.009）。双侧颈部Ⅱ、Ⅲ区是高危LNM区，IV、V区转移较少见；同侧Ⅱ、Ⅲ区转移是同侧Ⅳ区及对侧颈 LNM的相关因素，cN0期患者少见对侧颈LNM。
", "ds_process_way": "回顾分析2000-2017年中国医学科学院肿瘤医院初治局部晚期喉癌患者，所有患者至少行双颈Ⅱ－Ⅳ区淋巴结清扫，计算颈部各区LNM率。 采用Logistic回归分析LNM相关因素。
", "ds_quality": "数据质量良好
", "ds_acq_start_time": "2017-07-01 00:00:00", "ds_acq_end_time": "2019-12-31 00:00:00", "ds_acq_place": "甘肃兰州", "ds_acq_lon_east": null, "ds_acq_lat_south": null, "ds_acq_lon_west": null, "ds_acq_lat_north": null, "ds_acq_alt_low": null, "ds_acq_alt_high": null, "ds_share_type": "apply-access", "ds_total_size": 767352, "ds_files_count": 2, "ds_format": "pdf", "ds_space_res": null, "ds_time_res": "", "ds_coordinate": "无", "ds_projection": "", "ds_thumbnail": "b50d7463-a067-47cf-9245-3a7ad0759960.png", "ds_thumb_from": 0, "ds_ref_way": "", "paper_ref_way": "", "ds_ref_instruction": "", "ds_from_station": null, "organization_id": "9971252d-7beb-4464-bc08-bdcc5a1d7dd1", "ds_serv_man": "敏玉芳", "ds_serv_phone": "0931-4967596", "ds_serv_mail": "ncdc@lzb.ac.cn", "doi_value": "", "subject_codes": [], "quality_level": 3, "publish_time": "2023-08-25 09:38:55", "last_updated": "2023-08-27 15:45:04", "protected": false, "protected_to": null, "lang": "zh", "cstr": "11738.11.NCDC.IMP.DB3938.2023", "i18n": { "en": { "title": "Analysis on the regularity and related factors of cervical lymph node metastasis of locally advanced laryngeal carcinoma", "ds_format": "", "ds_source": "Objective to analyze the regularity of cervical lymph node metastasis (LNM) in locally advanced (T3, T4) laryngeal carcinoma, and to provide reference for neck target delineation in radiotherapy of laryngeal carcinoma. Methods: retrospective analysis of patients with locally advanced laryngeal cancer in Cancer Hospital of Chinese Academy of Medical Sciences from 2000 to 2017. All patients underwent at least bilateral neck lymph node dissection, and the LNM rate of each neck region was calculated. Logistic regression was used to analyze the related factors of LNM. The LNM rate was 57.1% (156 / 272). According to the location of the primary lesion, the patients were divided into three groups: group A (72 cases); In group B (8 cases), the main body of the primary lesion was deviated to one side but invaded the midline; In group C (114 cases), the primary lesion was huge or central. The LNM rate of different neck regions in group A was 36.3% in the ipsilateral cervical region II, 26.4% in the ipsilateral cervical region III and 6.9% in the ipsilateral cervical region IV, and 13.9%, 8.3% and 1.4% in the contralateral cervical region; Group B: ipsilateral cervical region II 41.9%, region III 29.1%, Region IV 11.6%, contralateral 18.6%, 14.0%, 1.2% respectively; In group C, 24.6%, 23.7% and 2.6% of left area II, area III and Area IV, and 21.9%, 26.3% and 6.1% of right area, respectively. The rate of bilateral LNM in group A was similar to that in group B and C (15.3% and 25.0%, P = 0.093). Whether the ipsilateral region III metastasis and clinical lymph node stage were associated with whether the contralateral neck was LNM (or = 2.929, 95% CI: 1.041-8.245, P = 0.042) and whether the contralateral neck was LNM (or = 0.082, 95% CI: 0.018-0.373, P = 0.001). Ipsilateral zone II and zone III metastasis were risk factors for ipsilateral Zone IV metastasis (P = 0.043, 0.009). Bilateral cervical regions II and III are high-risk LNM regions, and metastasis in regions IV and V is rare; Ipsilateral metastasis in region II and region III is a related factor of ipsilateral and contralateral cervical LNM. Contralateral cervical LNM is rare in cN0 patients.
", "ds_quality": "Good data quality
", "ds_ref_way": "", "ds_abstract": "This paper analyzed the regularity of cervical lymph node metastasis (LNM) in locally advanced (T3, T4) laryngeal carcinoma to provide reference for neck target delineation of radiotherapy for laryngeal carcinoma; Ipsilateral metastasis in region II and region III is a related factor of ipsilateral and contralateral cervical LNM. Contralateral cervical LNM is rare in cN0 patients.
", "ds_time_res": "", "ds_acq_place": "", "ds_space_res": "", "ds_projection": "", "ds_process_way": "Methods: retrospective analysis of patients with locally advanced laryngeal cancer in Cancer Hospital of Chinese Academy of Medical Sciences from 2000 to 2017. All patients underwent at least bilateral neck lymph node dissection, and the LNM rate of each neck region was calculated. Logistic regression was used to analyze the related factors of LNM.
", "ds_ref_instruction": "" } }, "submit_center_id": "ncdc", "data_level": 0, "license_type": "CC BY 4.0", "doi_reg_from": "reg_local", "cstr_reg_from": "reg_local", "doi_not_reg_reason": null, "cstr_not_reg_reason": null, "is_paper_in_submitting": false, "ds_topic_tags": [ "局部晚期", "喉癌", "淋巴结转移" ], "ds_subject_tags": [], "ds_class_tags": [], "ds_locus_tags": [ "兰州", "甘肃省" ], "ds_time_tags": [ 2017, 2018, 2019 ], "ds_contributors": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "ds_meta_authors": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "ds_managers": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "category": "其他" }