该文档是多粒子联合生物适形调强治疗计划方案，该方案基于PET-CT及f-MRI等多模态医学影像进行放疗计划设计。双重定位（CT 与f-MRI 或CT 与PET-CT）或三重定位(CT 与f-MRI 及PET-CT），经过图像融合进行靶区勾画，通过前期的研究已经显示出基于功能影像勾画靶区的优势。采用的X 射线放疗计划，正常组织损伤较大，剂量分布不均匀，同质子和重离子计划相比较，明显显示质子和重离子靶区设计较光子靶区设计更合理，剂量分布更均匀，射野更合理，周围正常组织受量明显降低，优势明显。
", "ds_source": "该研究目的是为了比较PET-CT及f-MRI功能扫描序列在确定放疗靶区中的作用，设计基于PET-CT及f-MRI影像的多粒子联合生物适形调强治疗计划方案。治疗方法是以鼻咽癌、肺癌、食管癌、直肠癌及结外鼻型NK/T细胞淋巴癌为代表病种，各选取10名患者，在各种影像序列上分别进行靶区勾画，确定各种影像使用手段用于指导靶区勾画时的最佳参数，设计基于功能影像的生物靶区。提供三种（包括光子、质子、重离子）治疗计划设计方案。比较三者的剂量分布及周围正常组织受量。试验结果是双重定位（CT与f-MRI或CT与PET-CT）或三重定位（CT与f-MRI及PET-CT），经过图像融合进行靶区勾画，通过前期的研究已经显示出基于功能影像勾画靶区的优势。采用的X射线放疗计划，正常组织损伤较大，剂量分布不均匀，同质子和重离子计划相比较，明显显示质子和重离子靶区设计较光子靶区设计更合理，剂量分布更均匀，射野更合理，周围正常组织受量明显降低，优势明显。
", "ds_process_way": "治疗方法是以鼻咽癌、肺癌、食管癌、直肠癌及结外鼻型NK/T细胞淋巴癌为代表病种，各选取10名患者，在各种影像序列上分别进行靶区勾画，确定各种影像使用手段用于指导靶区勾画时的最佳参数，设计基于功能影像的生物靶区。提供三种（包括光子、质子、重离子）治疗计划设计方案。比较三者的剂量分布及周围正常组织受量。
", "ds_quality": "报告中的医学图像数据均根据设备供应商提供的软件获得，相关的数据属于医疗数据。在对比光子、质子、重离子靶区计划设计的基础上，结合各自的优势，制定了多粒子联合治疗计划方案设计及计划实施流程，因质子和重离子目前刚应用于临床，下一步从临床方面进一步验证联合治疗的优势，更准确的界定联合治疗的具体剂量界限。从预后及毒副作用方面更进一步的验证方案设计的合理性。
", "ds_acq_start_time": "2017-07-01 00:00:00", "ds_acq_end_time": "2019-12-31 00:00:00", "ds_acq_place": "甘肃兰州", "ds_acq_lon_east": null, "ds_acq_lat_south": null, "ds_acq_lon_west": null, "ds_acq_lat_north": null, "ds_acq_alt_low": null, "ds_acq_alt_high": null, "ds_share_type": "apply-access", "ds_total_size": 31399383, "ds_files_count": 2, "ds_format": "pdf", "ds_space_res": null, "ds_time_res": "", "ds_coordinate": "无", "ds_projection": "", "ds_thumbnail": "f6ad44df-5602-4a73-873f-23c899dd238f.png", "ds_thumb_from": 2, "ds_ref_way": "", "paper_ref_way": "", "ds_ref_instruction": "", "ds_from_station": null, "organization_id": "9971252d-7beb-4464-bc08-bdcc5a1d7dd1", "ds_serv_man": "敏玉芳", "ds_serv_phone": "0931-4967596", "ds_serv_mail": "ncdc@lzb.ac.cn", "doi_value": "", "subject_codes": [], "quality_level": 3, "publish_time": "2022-08-26 17:38:31", "last_updated": "2023-08-23 16:47:51", "protected": false, "protected_to": null, "lang": "zh", "cstr": "11738.11.ncdc.IMP.db2503.2022", "i18n": { "en": { "title": "PET-CT and f-MRI based multi particle combined with biological intensity modulated therapy", "ds_format": "", "ds_source": "\nThe purpose of this study is to compare the role of PET-CT and f-MRI functional scanning sequences in determining the target area of radiotherapy, and design a multi particle combined biological conformal intensity modulation therapy plan based on PET-CT and f-MRI images. The treatment method is to take nasopharyngeal carcinoma, lung cancer, esophageal cancer, rectal cancer and extranodal nasal type NK / T cell lymphoid carcinoma as the representative diseases, select 10 patients each, conduct target area delineation on on various image sequences, determine the best parameters of various image use methods to guide target area delineation, and design biological target areas based on functional images. Three treatment plan design schemes (including photons, protons and heavy ions) are provided. The dose distribution of the three drugs and the dose of the surrounding normal tissues were compared. The test results are dual localization (CT and f-MRI or CT and PET-CT) or triple localization (CT and f-MRI and PET-CT). The target area is delineated through image fusion. Through the previous research, the advantage of target area delineated based on functional image has been shown. The adopted X-ray radiotherapy plan has relatively large damage to normal tissue and uneven dose distribution. Compared with the homoplasmon and heavy ion plans, it clearly shows that the proton and heavy ion target area design is more reasonable than the photon target area design, the dose distribution is more uniform, the radiation field is more reasonable, and the surrounding normal tissue dose is significantly reduced, with obvious advantages", "ds_quality": "
\nThe medical image data in the report are obtained according to the software provided by the equipment supplier, and the relevant data belong to medical data. On the basis of comparing the plan design of photon, proton and heavy ion target areas and combining their respective advantages, the plan design and plan implementation process of multi particle combined therapy are formulated. Since proton and heavy ion have just been applied in clinic, the next step is to further verify the advantages of combined therapy from the clinical perspective and define the specific dose limit of combined therapy more accurately. The rationality of the scheme design was further verified from the aspects of prognosis and side effects", "ds_ref_way": "", "ds_abstract": "
\nThis document is a multi particle combined biological conformal intensity modulation therapy plan, which is based on multi-modal medical images such as PET-CT and f-MRI for radiotherapy plan design. Dual localization (CT and f-MRI or CT and PET-CT) or triple localization (CT and f-MRI and PET-CT) and target area delineation through image fusion have shown the advantages of target area delineation based on functional images through previous studies. The adopted X-ray radiotherapy plan has relatively large damage to normal tissue and uneven dose distribution. Compared with the homoplasmon and heavy ion plans, it clearly shows that the proton and heavy ion target area design is more reasonable than the photon target area design, the dose distribution is more uniform, the radiation field is more reasonable, and the surrounding normal tissue dose is significantly reduced, with obvious advantages
", "ds_time_res": "", "ds_acq_place": "Lanzhou, Gansu", "ds_space_res": "", "ds_projection": "", "ds_process_way": "\nThe treatment method is to take nasopharyngeal carcinoma, lung cancer, esophageal cancer, rectal cancer and extranodal nasal type NK / T cell lymphoid carcinoma as the representative diseases, select 10 patients each, conduct target area delineation on on various image sequences, determine the best parameters of various image use methods to guide target area delineation, and design biological target areas based on functional images. Three treatment plan design schemes (including photons, protons and heavy ions) are provided. The dose distribution of the three drugs and the dose of the surrounding normal tissues were compared", "ds_ref_instruction": " " } }, "submit_center_id": "ncdc", "data_level": 0, "recommendation_value": 0, "license_type": "https://creativecommons.org/licenses/by/4.0/", "doi_reg_from": "reg_local", "cstr_reg_from": "reg_local", "doi_not_reg_reason": null, "cstr_not_reg_reason": null, "is_paper_in_submitting": false, "belong_to_nieer": false, "ds_topic_tags": [ "多粒子", "治疗计划", "方案" ], "ds_subject_tags": [], "ds_class_tags": [], "ds_locus_tags": [ "兰州", "甘肃省" ], "ds_time_tags": [ 2017, 2018, 2019 ], "ds_contributors": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "ds_meta_authors": [ { "true_name": "申国盛", "email": "sgs2005@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "ds_managers": [ { "true_name": "肖国青", "email": "xiaogq@impcas.ac.cn", "work_for": "中国科学院近代物理研究所", "country": "中国" } ], "category": "其他" }